In a situation where someone is not overconsuming calories or gaining weight, what health impacts do added sugars have?
#460: Dr. Priya Sumithran – Body Fat Regulation, Pros & Cons of Weight Loss Interventions, and GLP-1 Receptor Agonists
In this episode, Dr. Priya Sumithran discusses this physiologic control of body mass, in addition to environmental and behavioural factors that make weight loss maintenance difficult. Dr. Sumithran also discusses what this means for setting weight loss targets, choosing the correct intervention, and looking to non-weight-centric approaches for certain individuals. We also discuss the evidence on GLP-1 receptor agonist drugs, such as Semaglutide, as a treatment for obesity.
#429: Kevin Hall, PhD & Stephan Guyenet, PhD – Carbohydrate-Insulin Model vs. Energy Balance Model
The pathogenesis of obesity is clearly complex. And the need to have a comprehensive model to explain this pathogenesis is important. One such model, termed the Energy Balance Model, has largely been the consensus paradigm of obesity scientists to this point. However, there are others who propose that this is not the correct model of obesity, but rather that obesity pathogenesis can be better explained by a model called the Carbohydrate-Insulin Model (CIM) of obesity.
#395: Prof. Carel Le Roux – Current Thinking in Obesity Treatment
Professor le Roux is an expert in metabolic medicine and is currently a Professor of Experimental Pathology, University College Dublin. He is recognised as a world leader in metabolism and obesity. Professor le Roux’s clinical focus is in the management of Type 2 diabetes, pre-diabetes, obesity, cardiovascular risk and other metabolic disorders. Professor Carel le Roux has been published extensively and currently holds a number of editorial roles for journals in his field including, Clinical Obesity and Surgery for Obesity and Related Diseases.
#391: Is There a Body Weight Set Point?: Models of Body Mass Regulation
In this episode Danny and Alan discuss the three primary models used to explain body mass regulation: 1) Set Point Model, 2) Settling Point Model, 3) Dual Intervention Model. They discuss the role of feedback systems, environment, behaviour, as well as discussing both the “thrifty gene hypothesis” and John Speakman’s “drifty gene hypothesis”.
#388: Consequences of Weight Stigma and Weight Bias
Danny & Alan discuss the current evidence on the health consequences and societal consequences of weight stigma and weigh bias. This includes implicit bias, explicit bias, and internalization of bias. What evidence do we currently have? And what questions remain unanswered?
#379: Obesity & Chronic Disease Risk with Dr. Spencer Nadolsky
Guest InformationSpencer Nadolsky, DO Dr. Spencer Nadolsky is a board-certified obesity specialist, lipidologist, and family physician. Dr. Spencer uses lifestyle as medicine to treat and prevent chronic disease via telemedicine. He speaks all around the world about weight loss and health and is also the author of The Fat Loss Prescription and The Natural Way to Beat Diabetes.In this episode we discuss: BMI: strengths and limitations Adipose tissue type and relevance to risk Central/visceral adiposity has a different risk profile Hypertrophic vs. hyperplastic adipocytes Endocrine and inflammatory effects of different adipose tissue depots ‘Metabolically Healthy Obesity’ Weight bias and stigma Obesity …
#331: Prof. Roy Taylor – Diabetes Remission, Very-low Calorie Diets & the Twin Cycle Hypothesis
Guest InformationProf. Roy Taylor, MB ChB, MD Roy Taylor is Professor of Medicine and Metabolism at the University of Newcastle in the UK. There he is also director of the Newcastle Magnetic Resonance Centre. Prof. Taylor is an Honorary Consultant Physician at Newcastle Acute Hospitals NHS Trust. Since publishing his “twin cycle” hypothesis of type 2 diabetes in 2008, Prof. Taylor and colleagues have published several fascinating studies with potentially large implications for the potential to put diabetes into remission. Three of the most important trials were the Counterpoint Study, the Counterbalance study and the DiRECT study. All of which …
#324: Fatima Cody Stanford, MD – Obesity Treatment & Weight Bias
Find the podcast on your app of choice hereGuest InformationFatima Cody Stanford, MD, MPH, MPA Dr. Fatima Cody Stanford is an obesity medicine physician, scientist, educator, and policy maker at Massachusetts General Hospital and Harvard Medical School. She is a national and international sought after expert in obesity medicine who bridges the intersection of medicine, public health, policy, and disparities. She completed her Obesity Medicine & Nutrition Fellowship at MGH/HMS after completing her internal medicine and pediatrics residency at the University of South Carolina. She has served as a health communications fellow at the Centers for Disease Control and Prevention …