Ciarán Forde is a Professor in Sensory Science and Eating Behavior at Wageningen University in the Netherlands.
The PROPEL (Promoting Successful Weight Loss in Primary Care in Louisiana) trial was a cluster-randomized weight loss trial is specifically tailored to address the pressing health concerns of an underserved population in Louisiana, where obesity rates have reached alarming levels. In this episode we have the opportunity to delve deeper into the intricacies of the PROPEL trial and gain insights from one of its lead researchers, Dr. John Apolzan of the Pennington Biomedical Research Center.
In this episode, we will examine the evidence published to date and draw evidence-based conclusions regarding the impact of weight cycling on long-term health.
In a situation where someone is not overconsuming calories or gaining weight, what health impacts do added sugars have?
In this episode, Dr. Priya Sumithran discusses this physiologic control of body mass, in addition to environmental and behavioural factors that make weight loss maintenance difficult. Dr. Sumithran also discusses what this means for setting weight loss targets, choosing the correct intervention, and looking to non-weight-centric approaches for certain individuals. We also discuss the evidence on GLP-1 receptor agonist drugs, such as Semaglutide, as a treatment for obesity.
The pathogenesis of obesity is clearly complex. And the need to have a comprehensive model to explain this pathogenesis is important. One such model, termed the Energy Balance Model, has largely been the consensus paradigm of obesity scientists to this point. However, there are others who propose that this is not the correct model of obesity, but rather that obesity pathogenesis can be better explained by a model called the Carbohydrate-Insulin Model (CIM) of obesity.
Professor le Roux is an expert in metabolic medicine and is currently a Professor of Experimental Pathology, University College Dublin. He is recognised as a world leader in metabolism and obesity. Professor le Roux’s clinical focus is in the management of Type 2 diabetes, pre-diabetes, obesity, cardiovascular risk and other metabolic disorders. Professor Carel le Roux has been published extensively and currently holds a number of editorial roles for journals in his field including, Clinical Obesity and Surgery for Obesity and Related Diseases.
In this episode Danny and Alan discuss the three primary models used to explain body mass regulation: 1) Set Point Model, 2) Settling Point Model, 3) Dual Intervention Model. They discuss the role of feedback systems, environment, behaviour, as well as discussing both the “thrifty gene hypothesis” and John Speakman’s “drifty gene hypothesis”.
Danny & Alan discuss the current evidence on the health consequences and societal consequences of weight stigma and weigh bias. This includes implicit bias, explicit bias, and internalization of bias. What evidence do we currently have? And what questions remain unanswered?
Guest InformationSpencer Nadolsky, DO Dr. Spencer Nadolsky is a board-certified obesity specialist, lipidologist, and family physician. Dr. Spencer uses lifestyle as medicine to treat and prevent chronic disease via telemedicine. He speaks all around the world about weight loss and health and is also the author of The Fat Loss Prescription and The Natural Way to Beat Diabetes.In this episode we discuss: BMI: strengths and limitations Adipose tissue type and relevance to risk Central/visceral adiposity has a different risk profile Hypertrophic vs. hyperplastic adipocytes Endocrine and inflammatory effects of different adipose tissue depots ‘Metabolically Healthy Obesity’ Weight bias and stigma Obesity …
Guest InformationProf. Roy Taylor, MB ChB, MD Roy Taylor is Professor of Medicine and Metabolism at the University of Newcastle in the UK. There he is also director of the Newcastle Magnetic Resonance Centre. Prof. Taylor is an Honorary Consultant Physician at Newcastle Acute Hospitals NHS Trust. Since publishing his “twin cycle” hypothesis of type 2 diabetes in 2008, Prof. Taylor and colleagues have published several fascinating studies with potentially large implications for the potential to put diabetes into remission. Three of the most important trials were the Counterpoint Study, the Counterbalance study and the DiRECT study. All of which …
Find the podcast on your app of choice hereGuest InformationFatima Cody Stanford, MD, MPH, MPA Dr. Fatima Cody Stanford is an obesity medicine physician, scientist, educator, and policy maker at Massachusetts General Hospital and Harvard Medical School. She is a national and international sought after expert in obesity medicine who bridges the intersection of medicine, public health, policy, and disparities. She completed her Obesity Medicine & Nutrition Fellowship at MGH/HMS after completing her internal medicine and pediatrics residency at the University of South Carolina. She has served as a health communications fellow at the Centers for Disease Control and Prevention …