Prof. Roy Taylor, MB ChB, MD
Roy Taylor is Professor of Medicine and Metabolism at the University of Newcastle in the UK. There he is also director of the Newcastle Magnetic Resonance Centre. Prof. Taylor is an Honorary Consultant Physician at Newcastle Acute Hospitals NHS Trust.
Since publishing his "twin cycle" hypothesis of type 2 diabetes in 2008, Prof. Taylor and colleagues have published several fascinating studies with potentially large implications for the potential to put diabetes into remission.
Three of the most important trials were the Counterpoint Study, the Counterbalance study and the DiRECT study. All of which will be discussed in this episode.
In this episode we discuss:
- Diabetes and declining beta-cell function before diagnosis
- First-phase insulin response
- What causes type 2 diabetes
- Twin Cycle hypothesis
- Counterpoint study - 800kcal diet
- Counterbalance study: Stepped return to normal eating after a low-calorie intervention, aiming for weight maintenance
- DiRECT Study - why significant weight loss results in remission of Type 2 diabetes
- Why non-overweight people respond to weight-loss interventions as well as those in the overweight/obese MBI categories
- The Personal Fat Threshold
- What factors determine the likelihood of remission?
- Diabetes can be put into remission with weight loss, dietary changes, etc. – but “This knowledge must not be used as a stick with which to beat people who do not want to change their lives”
Links & Resources
- DiRECT Trial - Lean et al., 2018
- 2-year results of the DiRECT Trial - Lean et al., 2019
- Taylor, 2008 - Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause
- Lim et al., 2011 - Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
- Steven et al., 2016 - Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders
- Taylor, 2019 - Calorie restriction for long-term remission of type 2 diabetes
- Taylor et al., 2019 - Understanding the mechanisms of reversal of type 2 diabetes
- Taylor et al. ,2018 - Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery
- [Book] Life Without Diabetes: