SNP15: AMA – Semaglutide, “Carni-nutrients”, Sweating From Caffeine, & More

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Introduction

In this Premium-exclusive ‘Ask Me Anything’ episode, Danny answers a range of Premium subscriber questions…

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Questions Answered in this AMA

1. [00:03:01] Mechanisms that keeps weight stable over time?
2. [00:11:52] Semaglutide: Game-changer? Weight regain?
3. [00:30:42] How to further lower LDL-C? Can I avoid statins?
4. [00:43:52] Glyphosate: A cause for concern in food?
5. [00:48:30] High caffeine intake is making me sweat more. What’s going on?
6. [00:55:16] Should I avoid non-organic meat?
7. [01:00:08] Is there evidence on iron and zinc co-ingestion for anemia of prematurity?
8. [01:03:09] “Carni-nutrients”: Can vegan diets cause brain issues due to lower choline, creatine and taurine?
9. [01:12:10] Are energy drinks bad for us?
10. [01:17:43] What are some resources for doctors and patients that simply explain obesity & treatments?

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Related Resources

Question 1

• Sigma Statement: The “Calories In, Calories Out” Confusion: A Comprehensive Guide to Understanding Energy Balance
• Related episodes:
  • 68: Stephan Guyenet, PhD – Overeating, Fat Mass Regulation & Energy Homeostasis
  • 89: Dr. Michael Schwartz – Role of the Brain in Obesity, Insulin Resistance and Type 2 Diabetes Pathogenesis

Question 2

• Wharton et al., 2023 – Two-year effect of semaglutide 2.4 mg on control of eating in adults with overweight/obesity: STEP 5
• Wilding et al., 2021 – Once-Weekly Semaglutide in Adults with Overweight or Obesity
• Wilding et al., 2022 – Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension
• van Can et al., 2014 – Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults
• Blundell et al., 2017 – Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity
• Iepsen et al., 2015 – Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss
• Friedrichsen et al., 2021 – The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity

Question 3

• CCT Collaboration, 2019 – Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials
• Episode 439: Prof. David Jenkins – Lipid-Lowering Diets
• Jenkins et al., 2003 – Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein

Question 4

• Episode 437: GMOs & Genetic Engineering: Harmless or Health-Hazard?

Question 5

• Dunagan et al., 1998 – Thermoregulatory effects of caffeine ingestion during submaximal exercise in men
• Kim et al., 2011 – Caffeine increases sweating sensitivity via changes in sudomotor activity during physical loading
• Kwon et al., 2022 – Coffee intake may promote sudomotor function activation via the contribution of caffeine
• Hunt et al., 2021 – Caffeine alters thermoregulatory responses to exercise in the heat only in caffeine-habituated individuals: a double-blind placebo-controlled trial
• Lira et al., 2018 – Acute Caffeine Supplementation Does Not Change Sweat Rate and Blood Pressure in Ballet Dancers: A Double-Blind and Placebo-Controlled Study

Question 6

• Statement: Organic vs. Non-Organic Food: Is There a Difference?
• Średnicka-Tober et al., 2016 – Composition differences between organic and conventional meat: a systematic literature review and meta-analysis

Question 7

• Gibson et al., 2008 – Zinc, Gravida, Infection, and Iron, but Not Vitamin B-12 or Folate Status, Predict Hemoglobin during Pregnancy in Southern Ethiopia
• Houghton et al., 2016 – Serum Zinc Is a Major Predictor of Anemia and Mediates the Effect of Selenium on Hemoglobin in School-Aged Children in a Nationally Representative Survey in New Zealand
• Fischer Walker et al., 2005 – Interactive effects of iron and zinc on biochemical and functional outcomes in supplementation trials
• Elhendy et al., 2001 – Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats
• Kondaiah et al., 2021 – Effect of zinc depletion/repletion on intestinal iron absorption and iron status in rats

Question 8

• Episode #463: Do Vegan Diets Cause Depression?
• Bjelland et al., 2009 – Choline in anxiety and depression: the Hordaland Health Study
• Caine et al., 2016 – Taurine, energy drinks, and neuroendocrine effects
• Blancquaert et al., 2018 – Changing to a vegetarian diet reduces the body creatine pool in omnivorous women, but appears not to affect carnitine and carnosine homeostasis: a randomised trial

Question 9

• Caine et al., 2016 – Taurine, energy drinks, and neuroendocrine effects
• Nadeem et al., 2021 – Energy Drinks and Their Adverse Health Effects: A Systematic Review and Meta-analysis

Question 10

• mybestweight.ie/education
• itsnotyourfault.ie

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Transcript

SNP15 AMA – TranscriptDownload

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