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SNR #88: Kevin Hall, PhD – The Physiology of Fat Loss, Weight Regain & Carb or Fat Restriction?

In Podcasts by Danny Lennon4 Comments

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Episode 88: Dr. Kevin Hall of the NIH is on to discuss the recent carb restriction vs. fat restriction study, issues surrounding weigh regain, homeostatic regulation of weight and the physiology of fat loss.

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Guest Bio

Kevin Hall, PhD


Dr. Hall’s laboratory investigates how metabolism and body composition adapt in response to a variety of interventions. They perform experiments in both humans and rodents to better understand the complex mechanisms regulating macronutrient metabolism, body composition, and energy expenditure. A unique aspect of the laboratory involves the development of mathematical models to quantitatively describe, explain, integrate, and predict our experimental results.

In this episode we discuss:

  • The recent carbohydrate restriction vs. fat restriction study
  • Homeostatic mechanisms that underpin calorie intake and expenditure
  • Taking an integrated view of energy balance, hormones and external food cues
  • Using mathematical models to predict calorie intake and/or bodyweight changes
  • The future of obesity research

Links & Resources:

Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity – Hall et al.

Validation of an inexpensive and accurate mathematical method to measure long-term changes in free-living energy intake – Sanghvi et al.

NIH Body Weight Planner

Predicting metabolic adaptation, body weight change, and energy intake in humans

Modeling metabolic adaptations and energy regulation in humans

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