#376: Kevin Hall, PhD – Plant-based Diet vs. Ketogenic Diet: Impact on Calorie Intake

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Kevin Hall, PhD

Dr. Kevin Hall, PhD is Senior Chief of the Integrative Physiology Section of the Laboratory of Biological Modeling at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

His laboratory investigates how metabolism and the brain adapt in response to a variety of interventions to diet and physical activity. They carry out studies to better understand the complex mechanisms regulating macronutrient metabolism, body composition, and energy expenditure.

Recently Dr. Hall was lead author on a study titled 'Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake', which was published in Nature Medicine in early 2021.

[Disclaimer: By participating in this podcast, the U.S. Government, represented by the National Institutes of Health does not directly or indirectly endorse any product or service provided, or to be provided, by Sigma Nutrition.]

In this episode we discuss:

  • The recent study published by Dr. Hall and colleagues, titled 'Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake'.
  • The 'Passive Overconsumption' model of obesity
  • The Carbohydrate-Insulin model of obesity
  • How the study was designed to test the predictions of each of these models
  • Results and interpretation of the results
  • Misconceptions and misinterpretations of the study results
  • Implications for the hypotheses and future research
  • How should we define and measure "keto-adaptation"?

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