SNR #164: Dominic D’Agostino, PhD – Press-Pulse Model of Cancer Therapy, Ketones & Metabolic Drugs

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Episode 164: Dominic D’Agostino, PhD of the University of South Florida and the Institute for Human and Machine Cognition discusses his lab’s research onto various treatment therapies for cancer including nutritional ketosis, hyperbaric oxygen therapy and metabolic drugs.

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Guest Bio


Dominic D’Agostino, Ph.D.

Dr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). The primary focus of his laboratory is developing and testing metabolic-based therapies, including ketogenic diets, ketone esters, ketone supplements and metabolic-based drugs. His research also explores the use of these metabolic therapies for a broad range of disorders linked pathophysiologically to metabolic dysregulation, including seizures, neurological disorders, wound healing, muscle wasting and cancer. The laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies.

In This Episode We Discuss:

  • Cancer as a metabolic disease
  • Potential mechanisms of action for ketosis being a beneficial metabolic state in cancer patients
  • Ketosis, calorie restriction, hyperbaric oxygen therapy and metabolic drugs as adjunct therapies in cancer treatment
  • Possible future avenues of research
  • What research needs to be done for this research to become seen more in front-line clinical practice
  • Barriers to implementation

Links & Resources

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer – Seyfried et al., 2017

Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells – Grabacka et al., 2016

Role of ketogenic metabolic therapy in malignant glioma: A systematic review – Winter et al.,  2017

Cancer as a metabolic disease: implications for novel therapeutics – Seyfried et al., 2013

Hyperbaric Oxygen Therapy

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer – Poff et al., 2013

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