Episode 169: Molecular physiologist Chad Macias, of the Institute for Human Kinetics, discusses some limitations of research, issues of misinterpretation and/or inaccurate communication related to research on cancer, nutritional ketosis and the press-pulse method.
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Chad is currently pursuing post-graduate research in Molecular Oncology. He is in the process of writing a review paper on ketogenic diets and cancer, along with Brad Dieter and Tim Sharpe. Chad has spent over 19 years conducting research and developing protocols in cellular and molecular physiology. He is an adjunct faculty member at the University of San Diego, and has developed some of the most advanced blood lactate testing and intermittent hypoxia protocols in the world.
He founded the Institute for Human Kinetics in 2011, where he works with many of the world’s top athletes. In addition, he was a two sport Olympic athlete. He also serves as the Human Performance Specialist at Navy Special Warfare developing programs to prepare Navy Seals for combat deployment though their Tactical Athlete Program. Chad also heads OPI’s Research Team and has the knowledge base to conduct medical and exercise physiology research in both humans and rodents.
In this episode we discuss:
- How ketones have the potential to accelerate tumour growth in some cancers
- Why you can’t “starve cancer cells” with a ketogenic diet
- The complexity of cancer
- Is cancer a genetic disease, metabolic disease or both?
- Issues with the way some cancer research is being interpreted and communicated
- Criticisms of the conclusions being made based on the experimental models used
- Why recommending cancer patients embark on a ketogenic diet is premature & potentially counter-productive
Links & Resources:
- Ep 164 w/ Dominic D’Agostino, PhD
- Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments – Henderson et al., 2013
- Institute for Human Kinetics (IHK) Biomedical Research Lab
- Institute for Human Kinetics
- Sigma Weight Cutting System
- Support the podcast on Patreon
- Click Here to Get Podcast Transcripts
References Related to Chad Macias’ Points:
- Points Highlighted by Chad Macias [PDF file with list of points with supporting references]
References Related to Dominic D’Agositino’s Points:
- Press-pulse: a novel therapeutic strategy for the metabolic management of cancer – Seyfried et al., 2017
- Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells – Grabacka et al., 2016
- Role of ketogenic metabolic therapy in malignant glioma: A systematic review – Winter et al., 2017
- Cancer as a metabolic disease: implications for novel therapeutics – Seyfried et al., 2013
- The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer – Poff et al., 2013
- The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma – Abdelwahab et al., 2012