#407: Polyphenols – Impact on Blood Pressure, Endothelial Function & Heart Disease Risk

In Podcasts by Danny Lennon1 Comment

Today's Topic in Focus:  [03:01]

In this episode we discuss the potential impact of dietary polyphenols on cardiovascular disease risk; including impacts on blood pressure, flow-mediated dilation, and other related outcomes. We talk about some potential mechanisms and then several specific randomized, controlled trials.


  1. Medina-Remón et al., 2015 - Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial
  2. Odai et al., 2019 - Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension
  3. Sánchez Macarro et al., 2020 - Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Disease Risk
  4. Della Pepa et al., 2019 - Effects of a diet naturally rich in polyphenols on lipid composition of postprandial lipoproteins in high cardiometabolic risk individuals
  5. Bondonno et al., 2012 - Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women
  6. Mills et al., 2017 - Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites
  7. Coffee & Health Podcast Episode

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