SNR #167: Dom D’agostino, PhD – Traumatic Brain Injury, CTE & Implications for Combat Sport Athletes

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Episode 167: Dominic D’Agostino, PhD returns to the show to discuss issues related to traumatic brain injury (including CTE) and associations with contact sports such as boxing, MMA and American football.

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Guest Bio


Dominic D’Agostino, Ph.D.

Dr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). The primary focus of his laboratory is developing and testing metabolic-based therapies, including ketogenic diets, ketone esters, ketone supplements and metabolic-based drugs. His research also explores the use of these metabolic therapies for a broad range of disorders linked pathophysiologically to metabolic dysregulation, including seizures, neurological disorders, wound healing, muscle wasting and cancer. The laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies.

In This Episode We Discuss:

  • Development of chronic TBI
  • Chronic traumatic encephalopathy (CTE) and association with combat sports and American football
  • Potential risk reduction strategies for combat sport athletes
  • What’s going on in the brain after injury? – GABA, glutamate, elctrolytes, etc.
  • Substrate metabolism in the brain and neuro-inflammatory response after injury

Links & Resources

What is CTE? – Brain Injury Research Institute

Signs of brain injuries in young NFL players adds to evidence linking concussions, CTE

Why Jordan Parsons’ CTE diagnosis matters, even if it’s not completely surprising [MMA-Junkie]

What boxing tells us about repetitive head trauma and the brain

The evidence for chronic traumatic encephalopathy in boxing – McCrory et al., 2007

Sigma Weight Cutting System for MMA & Boxing

Shredded By Science Academy 

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