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SNR #129: Chris Masterjohn, PhD – Glycation, Oxidative Stress & The Protective Effects of Glucose and Insulin

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Episode 129: Chris Masterjohn, PhD discusses the role of carbohydrates and insulin in endogenous antioxidant systems, oxidative stress and misconceptions on glycation.

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Guest Bio

Chris Masterjohn, PhD



Chris is currently Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. He has a PhD in Nutritional Sciences from the University of Connecticut.

His dissertation was about the role of glutathione, an antioxidant and detoxifying molecule that we make within our own bodies from dietary protein, in preventing the accumulation of methylglyoxal, a potentially toxic compound formed in small amounts during energy metabolism that is believed to play a role in diabetes and other degenerative diseases.

He writes detailed nutritional science articles on his blog and hosts a podcast, Mastering Nutrition.

In this episode we discuss:

  • Why it’s important people don’t fall into the trap of demonizing sugar in the same way they argue other have done to dietary fat in the past.
  • The realtionship between oxidative stress, glycation and diet.
  • The role of glucose and insulin in our bodies’ antioxidant systems
  • Why restricting carbohydrates out of fear they increase glycation is erroneous

Links & Resources:

The Daily Lipid Blog

The Daily Lipid Podcast

Summary Post on Glycation and AGEs

AH2 2012 Presentation on Oxidative Stress & Carbohydrate Intolerance


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Related Episodes:

SNR #68: Stephan Guyenet – Overeating, Fat Mass Regulation & Energy Homeostasis

SNR #38: Dan Pardi – Sleep, Circadian Rhythms & the Importance of Light & Dark


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