#500 – The Big Unanswered Questions in Nutrition Science

In Podcasts by Danny LennonLeave a Comment


To mark the 500th episode of the podcast, Danny and Alan take a look at some of the current outstanding questions in nutrition science, what areas have largely been resolved, and how their own thinking has evolved and changed over time.

This brings them into areas such as personalized nutrition, ultra-processed foods, time-restricted eating, salt & health, and the difference between being “evidence-based” and “reference-based”.

Co-hosts for this Episode

Dr. Alan Flanagan has a PhD in nutrition from the University of Surrey, where his doctoral research focused on circadian rhythms, feeding, and chrononutrition.

This work was based on human intervention trials. He also has a Masters in Nutritional Medicine from the same institution.

Dr. Flanagan is a regular co-host of Sigma Nutrition Radio. He also produces written content for Sigma Nutrition, as part of his role as Research Communication Officer.

Danny Lennon has a master’s degree (MSc.) in Nutritional Sciences from University College Cork, and he is the founder of Sigma Nutrition.

Danny is currently a member of the Advisory Board of the Sports Nutrition Association, the global regulatory body responsible for the standardisation of best practice in the sports nutrition profession.


  • Outstanding questions in nutrition science
    • Personalized nutrition
    • Ultra-prosessed foods (UPFs)
    • Diet-Microbiome-Health
    • Omega-3 Fatty Acids
  • Largely resolved questions
    • Sodium & CVD risk
    • TRE/TRF
    • Macronutrient breakdown & weight loss
  • Evolution in our thinking
    • Epistemology at the forefront
    • “Reference-based” to evidence-based
    • Reading research: understanding “highest quality evidence”

Previous episodes referenced:

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