#456: Prof. Glenn McConell – Glucose Uptake During Exercise & Muscle Insulin Sensitivity

In Podcasts by Danny Lennon2 Comments

Table of Contents

  1. Introduction
  2. Guest Information
  3. Related Resources
  4. Detailed Study Notes (Premium Subscribers Only)
  5. Transcript (Premium Subscribers Only)


Exercise improves metabolic control both via increasing muscle glucose uptake during muscle contractions by insulin-independent mechanisms and by increasing skeletal muscle insulin sensitivity after physical activity. A reduction in skeletal muscle insulin sensitivity is an early event in the development of not only prediabetes, metabolic syndrome, and type 2 diabetes but is also associated with other conditions such as cardiovascular disease and some cancers.

One of the researchers that has been at the forefront of research in this area for many years is Professor Glenn McConell. In this episode we discuss glucose uptake during and after exercise, looking at both insulin-dependent and insulin-independent mechanisms. In addition we discuss the crucial importance of muscle insulin sensitivity and some important research breakthroughs on the topic.

Guest Information

Prof. Glenn McConell, PhD

Glenn McConell is Emeritus Professor at Victoria University, where he previously was Professor of Exercise Metabolism. He has 30 years’ experience in exercise metabolism research and is internationally recognized in regard to the regulation of skeletal muscle glucose uptake in normal physiology and in diabetes. His research focuses on glucose metabolism and exercise. This work has included examining the factors that regulate skeletal muscle glucose uptake during exercise and the increase in insulin sensitivity after exercise. Prof. McConell is the host of the Inside Exercise podcast, where he interviews the biggest names in the world of sports science academia. He is also the editor of the renowned textbook ‘Exercise Metabolism’.

  • Mentioned studies:
    • Sjoberg et al., 2017 – Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling
    • McConell et al., 2020 – Insulin-induced membrane permeability to glucose in human muscles at rest and following exercise
    • McConell, 2020 – It’s well and truly time to stop stating that AMPK regulates glucose uptake and fat oxidation during exercise
    • Bescos et al., 2018 – Four days of simulated shift work reduces insulin sensitivity in humans
  • Inside Exercise Podcast:
  • Exercise Metabolism (textbook)

Detailed Study Notes

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  1. I have exercise sensitivity on extreme exercise.
    I was ir and t2 for over 30 yrs. now non diabetic with HbA1c circa 40.
    Started lc/hf with 16/8 if 16 months ago.
    I exercise 6-7 times per wk. Split HIIT spin and resistance training.

    I’m 66 and still pb’ing.

    Just discovered the spikes on trial of cgm.
    Would like to know more about my specific t2?

    Grateful if you could point me in good direction on this.
    I’m from UK.


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