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Folate (also known as vitamin B9) actually relates to a collection of folates; both natural dietary folates and synthetic forms, primarily folic acid. This folate/folic acid that is consumed via the diet or supplementation is a precursor for the formation of tetrahydrofolate (THF), which is a carbon donor and acts a cofactor for a number of enzymes that play important roles in several processes.
In this episode, Alan and Danny discuss the role of folate in the methlyation cycle, the impact of folate insufficiency/deficiency, genetics variants of the MTHFR gene (and other genes) that impact folate metabolism, and the impact of folate on health outcomes; including heart disease, birth defects, cancer, and brain health & cognition.
- What is Folate?
- Dietary Folate Equivalents (DFEs)
- One-Carbon Metabolism & the Folate Cycle
- Folate Deficiency
- Genetic Variants
- Neural Tube Defects
- Other Pregnancy Outcomes
- Cardiovascular Disease
- Cognitive Impairment
Detailed Study Notes