#444: Folate – Intake, Genetics & Health Outcomes

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Table of Contents

  1. Introduction
  2. Overview
  3. Related Resources
  4. Detailed Study Notes (Premium Subscribers Only)
  5. Transcript (Premium Subscribers Only)

Introduction

Folate (also known as vitamin B9) actually relates to a collection of folates; both natural dietary folates and synthetic forms, primarily folic acid. This folate/folic acid that is consumed via the diet or supplementation is a precursor for the formation of tetrahydrofolate (THF), which is a carbon donor and acts a cofactor for a number of enzymes that play important roles in several processes.

In this episode, Alan and Danny discuss the role of folate in the methlyation cycle, the impact of folate insufficiency/deficiency, genetics variants of the MTHFR gene (and other genes) that impact folate metabolism, and the impact of folate on health outcomes; including heart disease, birth defects, cancer, and brain health & cognition.


Overview

  • What is Folate?
  • Dietary Folate Equivalents (DFEs)
  • One-Carbon Metabolism & the Folate Cycle
  • Folate Deficiency
  • Genetic Variants
  • Neural Tube Defects
  • Other Pregnancy Outcomes
  • Cardiovascular Disease
  • Cancer
  • Cognitive Impairment

Detailed Study Notes

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Transcript

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