#444: Folate – Intake, Genetics & Health Outcomes

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Table of Contents

  1. Introduction
  2. Overview
  3. Related Resources
  4. Premium Content
    • Detailed Study Notes
    • Transcript


Folate (also known as vitamin B9) actually relates to a collection of folates; both natural dietary folates and synthetic forms, primarily folic acid. This folate/folic acid that is consumed via the diet or supplementation is a precursor for the formation of tetrahydrofolate (THF), which is a carbon donor and acts a cofactor for a number of enzymes that play important roles in several processes.

In this episode, Alan and Danny discuss the role of folate in the methlyation cycle, the impact of folate insufficiency/deficiency, genetics variants of the MTHFR gene (and other genes) that impact folate metabolism, and the impact of folate on health outcomes; including heart disease, birth defects, cancer, and brain health & cognition.


  • What is Folate?
  • Dietary Folate Equivalents (DFEs)
  • One-Carbon Metabolism & the Folate Cycle
  • Folate Deficiency
  • Genetic Variants
  • Neural Tube Defects
  • Other Pregnancy Outcomes
  • Cardiovascular Disease
  • Cancer
  • Cognitive Impairment

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