#421: Brendon Stubbs, PhD – The Research on Depression & Physical Activity

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Brendon Stubbs, PhD

Dr. Brendon Stubbs, PhD, is a Senior Clinical Lecturer and researcher at King's College London, conducting research in physical activity & mental health, the mind-body interface, and meta-research. He has published over 650 academic papers in several leading journals across multiple scientific fields.

Dr. Stubbs is also a clinical physiotherapist, being Head of Physiotherapy at the South London and Maudsley NHS Foundation Trust. He has a MSc in Neurological Rehabilitation & PhD in Pain Medicine & Rehabilitation. He has also informed policy guidelines in the UK, Europe and the World Health Organization.

In this episode we discuss:

  1. Movement levels as a risk factor, most notably depression
  2. A meta-analysis of prospective cohort studies in 2018, looking at physical activity and incident depression.
  3. This link between movement and depression has been looked at in some Mendelian Randomization studies
  4. Those who had a genetic pre-disposition to depression, but were most active had lower risk, than those who were less active
  5. Meta-analyses: the good and the bad
  6. What is "success" in terms of an intervention and depression
  7. Heterogeneity of exposure (activity type) and outcome (symptoms, diagnosis, etc.)
  8. Multifacted and complex nature of depression

Links & Resources

  • Click here to join the email list to receive our weekly Sigma Synopsis emails
  • Schuch et al., 2018 - Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies
  • Schuch et al., 2016 - Are lower levels of cardiorespiratory fitness associated with incident depression? A systematic review of prospective cohort studies
  • Choi et al., 2019 - Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study
  • Schuch & Stubbs, 2019 - The Role of Exercise in Preventing and Treating Depression
  • Kandola et al., 2019 - Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity
  • Instagram: @brendon.stubbs

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