#294: Nicola Guess, PhD, RD – Prediabetes & Type 2 Diabetes Nutrition

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Guest Bio

Nicola Guess, PhD, RD

Nicola Guess is a Registered Dietitian with a PhD in the dietary management of prediabetes from Imperial College London. She is currently Head of the Nutrition Unit at Dasman Diabetes Institute (DDI) in Kuwait. Nicola is a research fellow at King’s College London where her research focuses on the role of diet in the prevention and management of type 2 diabetes.

She has a particular interest in the use of low-carbohydrate diets in the management of type 2 diabetes, and leads a research programme investigating dietary modification – including increasing protein or the use of very-low-calorie-diets – on the factors underlying type 2 diabetes.

Nicola received her Registered Dietitian qualification in the United States which included clinical rotations at the Baylor College of Medicine, and world-famous Weight Management Clinic at the Methodist Hospital in Houston, Texas.

Nicola’s expertise in the area of diet and type 2 diabetes is well recognised. She is currently a National Institute of Clinical Excellence (NICE) Guidelines Expert Adviser and was a Diabetes UK Research Fellow. She sits on the Diabetes UK Clinical Guidelines Committee which sets priorities for diabetes research in the UK; is a panel member of the Royal College of General Practitioners Lifestyle Group and was previously a topic expert on the NICE Guidelines Committee for the Prevention of Type 2 Diabetes.

In This Episode We Discuss

  • Type 2 diabetes as a progressive disease
  • Declining beta-cell function
  • Relationship between insulin resistance and decline in beta-cell function
  • Two types of prediabetes: a) elevated fasting BG but normal OGTT, b) normal fasting BG but elevated 2 hour OGTT
  • Postprandial glucose excursions
  • Can type 2 diabetes be reversed? Remission vs. reversal
  • Diabetes Remission Clinical Trial (DiRECT)
  • VIRTA health trial
  • Nutritional interventions: weight loss, carbohydrate restriction, fasting, etc.
  • Weight loss: why does it lead to remission or improvement in biomarkers?
  • Best blood markers to monitor?

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