Episode 195: Dr. Brendan Egan of Dublin City University discusses the current research on exogenous ketone supplementation for athletic performance and recovery.
Brendan Egan, PhD
Brendan holds a position as Senior Lecturer in Sport and Exercise Physiology in the School of Health and Human Performance at Dublin City University. His current research investigates the molecular regulation of skeletal muscle function and adaptation across the life course, with special interest in the synergy between nutrition and exercise interventions to optimise performance in athletes and elderly.
He received his BSc Sport and Exercise Science from the University of Limerick in 2003, MSc Sport and Exercise Nutrition from Loughborough University in 2004, and PhD from Dublin City University in 2008, before completing two years of post-doctoral training with Prof. Juleen Zierath’s Integrative Physiology group at the Karolinska Institute, Sweden. His doctoral studies focussed on skeletal muscle adaptation to exercise, and in particular the continuity between acute molecular responses to individual bouts of exercise and adaptations induced by exercise training, whereas his post-doctoral training utilised animal models and in vitro cell systems to investigate the transcriptional regulation of skeletal muscle development and mechanisms of insulin resistance.
He joined the faculty in the School of Public Health, Physiotherapy, and Sport Science at University College Dublin in 2011, where he spent five years, and retains a position as Visiting Associate Professor. On the sporting front, he has played inter-county Gaelic football with Sligo since 2003, and consults as a performance nutritionist to elite team sport athletes
In This Episode We Discuss:
- Ketone body definitions
- Endogenous vs. exogenous ketones
- The problem with conflating a state of ketosis with supplementation with exogenous ketones
- Proposed mechanisms for exogenous ketones improving performance
- Results from research thus far
- Applications for recovery and inducing adaptations
- Ketones as anti-lipolytic
Links & Resources
- Evans, Cogan & Egan, 2017 – Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation
- Egan & D’agostino, 2016 – Fueling Performance: Ketones Enter the Mix
- O’ Malley et al., 2017 – Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males
- Vandoorne et al., 2017 – Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle
- Holdsworth et al., 2017 – A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans
- Pinckaers et al., 2017 – Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?
- Sigma Nutrition Seminar – November 2017 (Dublin & London)
- Precision Nutrition Free Course for Sigma Nutrition Radio Listeners
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