Episode 123: Donald Layman PhD, professor emeritus at the University of Illinois, discusses the “leucine threshold” and activation of the mTOR pathway, amino acid oxidation and why MPS drops 2-3 hours after that peaking even when protein remains being fed.
Donald Layman, PhD.
Dr. Layman is professor emeritus at the University of Illinois. Dr. Layman’s laboratory is working to define protein and amino acid requirements and the interrelationship between dietary protein and carbohydrates in adult health. His research is focused on the impact of diet and exercise on adult health problems of obesity, type 2 diabetes and the Metabolic Syndrome.
His lab are continuing this research to define mechanisms for control of muscle protein synthesis and differences in dietary protein needs for men versus women and for adults with sedentary versus active lifestyles.
In this episode we discuss:
- What should we define as a “high-protein” diet?
- Making protein recommendations on a per meal basis
- The “leucine threshold” and activation of the mTOR pathway
- Other metabolic signals triggered off by amino acids that play a role in health
- The roles of insulin and leucine in mTOR activation – shifts in their contribution over time
- Why oxidation of amino acids does not mean they are “wasted”
- Why MPS drops 2-3 hours after that peaking even when protein remains being fed
- Protein synthesis as an energy expensive process
- Leucine kinetics
- Protein leverage hypothesis