SNP12: The Big Breakfast Study

In Podcasts by Danny LennonLeave a Comment

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Table of Contents

  1. Introduction
  2. Further Reading
  3. Transcript (Premium Subscribers Only)


In October 2022, Ruddick-Collins et al. published results of an RCT looking at the impact of different calorie distributions across the day. This study was from the ‘Big Breakfast Study’ project, primarily from the University of Aberdeen.

In this study, 30 subjects underwent two 4-week calorie-restricted diets that were matched for calories. One diet was “morning-loaded”, meaning that daily calories were distributed as 45% at breakfast, 35% at lunch, and 20% at dinner. The other was “evening-loaded”, with an opposing calorie distribution; i.e., 20% at breakfast, 35% at lunch, and 45% at dinner.

The trial received a lot of commentaries online after it was published. However, much of it lacked sufficient context, nuance, and understanding of the implications.

In this episode, Dr. Alan Flanagan, who was one of the researchers involved in some of the work of the Big Breakfast Study, gives an insight into the recently published paper by Ruddick-Collins et al., and highlights some important aspects to be aware of.

From: Ruddick-Collins et al., Cell Metab. 2022 Oct 4; 34(10): 1472–1485.e6

Further Reading

  1. Ruddick-Collins et al., 2022 – Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity
  2. Ruddick-Collins et al., 2018 – The Big Breakfast Study: Chrono-nutrition influence on energy expenditure and bodyweight
  3. Ruddick-Collins et al., 2022 – Circadian Rhythms in Resting Metabolic Rate Account for Apparent Daily Rhythms in the Thermic Effect of Food
  4. Morris et al., 2015 – The human circadian system has a dominating role in causing the morning/evening difference in early diet-induced thermogenesis
  5. Jakubowicz et al., 2013 – High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women


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