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SNR #: Andy Philip, PhD – Molecular Regulation of Skeletal Muscle Adaptation

  • by Danny Lennon
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Guest Bio

Andy Philip, PhD

Dr Andy Philip is an integrative physiologist, interested in the molecular regulation of skeletal muscle adaptation. The main focus of his work is to examine how diet and exercise interact to regulate skeletal muscle mitochondrial function, adaptive growth and insulin sensitivity in the context of human athletic performance and in metabolic diseases such as sarcopaenia, obesity and type 2 diabetes.

Dr Andrew Philp is a Senior lecturer in Integrative Physiology in the MRC-ARUK Centre for Musculoskeletal Ageing Research at the University of Birmingham (UoB). Andy is an established principal investigator with an international reputation of excellence in characterising the molecular regulation of skeletal muscle in response to activity and nutrition. This excellence is evidenced by the publication of over 40 peer-reviewed publications, in addition to 3 book chapters. Andy has published original research articles in high impact journals such as Cell, Journal of Clinical Investigation, Oncogene, Diabetes, Diabetelogia and the Journal of Biological Chemistry and reviewed manuscripts for ~20 peer reviewed journals, most recently invited to serve on the editorial board of PLoS One. Evidence of Andy’s development as a principal investigator is reflected in invitations to speak at national (The Physiological Society, BASES) and international (European College of Sport Sciences, American College of Sports Medicine (ACSM), Integrative Physiology of Exercise, Experimental Biology) conferences over the past 4 years.

Thequality of Andy’s research is reflected by New Investigator awards from the American Physiological Society and the RANK prize nutrition funds in addition to being the recipient of the 2012 University of California Davis award for excellence in post-doctoral research. In the past 3 years, since joining UoB, Andy has secured research funding in the form of RCUK PhD studentships (BBSRC, MRC), post-doctoral fellowships (Sir Henry Wellcome Post-doctoral fellowship, Kidney Research UK fellowship) and industry-related research grant funding. Most notably, Andy was the recent recipient of a New Investigator Award from the BBSRC in 2014 examining the role of the acetyltransferase GCN5 on skeletal muscle adaptation to endurance exercise and recently received funding from the UoB dynamic investment fund to establish a mitochondrial profiling centre, in which he will operate as the director. Currently the Philp research group consists of 4 PDRF, 4 PhD students, 1 research assistant and 3 Masters students (MRes & MSc).

In This Episode We Discuss

  • Regulatory role of glycogen in skeletal muscle adaptation
  • Effect of glycogen depletion on adaptive response to exercise
  • Is there a threshold at which glycogen depletion starts to increase cellular signalling
  • Does low glycogen availability affect performance in non-glycolytic sports like weightlifting?
  • Novel regulators of mitochondrial biogenesis in human skeletal muscle

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