Table of Contents
- Introduction
- Guests
- Overview
- Related Resources
- Premium Content
- Detailed Study Notes
- Transcript
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Introduction
In episode 529 of Sigma Nutrition Radio, we discuss all things related to cholesterol, atherosclerosis, heart disease, and dietary fat. The discussion extensively covers the impact of LDL cholesterol and ApoB on atherosclerotic plaque progression, cardiovascular events, and the benefits of early LDL lowering interventions, particularly through the use of PCSK9 inhibitors alongside statins.
We address misconceptions prevalent in the low-carb and carnivore communities, dissect claims regarding saturated fats, and elucidate why atherosclerosis predominantly affects arteries and not veins. The episode sheds light on the nuanced mechanisms of cholesterol metabolism, the significance of different lipid particles, and the limited dietary impact on LP(a) levels.
Comprehensive evidence-based insights and practical recommendations for dietary patterns and cardiovascular health interventions are provided, offering clarity on these complex topics.
Note: This discussion is hosted by Simon Hill, and originally appeared as an episode of The Proof podcast.
Guests in this Episode
Dr. Alan Flanagan has a PhD in nutrition from the University of Surrey, where his doctoral research focused on circadian rhythms, feeding, and chrononutrition.
This work was based on human intervention trials. He also has a Masters in Nutritional Medicine from the same institution.
Dr. Flanagan is a regular co-host of Sigma Nutrition Radio. He also produces written content for Sigma Nutrition, as part of his role as Research Communication Officer.
Danny Lennon has a master’s degree (MSc.) in Nutritional Sciences from University College Cork, and he is the founder of Sigma Nutrition.
Danny is currently a member of the Advisory Board of the Sports Nutrition Association, the global regulatory body responsible for the standardisation of best practice in the sports nutrition profession.
Overview
- 07:19 Understanding Cholesterol and Lipoproteins
- 14:35 The Role of ApoB in Cardiovascular Risk
- 25:10 Atherogenic Lipoproteins and Their Impact
- 37:42 Causal Pathways and Biomarkers in Heart Disease
- 47:02 Understanding Residual Risk and Triglycerides
- 49:46 Paul Saladino’s Claims on LDL and Metabolic Health
- 01:03:01 Addressing Concerns About Lowering Cholesterol
- 01:16:16 The Importance of Early Intervention in Cholesterol Management
- 01:23:36 The Future of Cholesterol Management and Gene Editing
- 01:28:24 Atherosclerosis in Arteries vs. Veins
- 01:36:08 Dietary Interventions to Lower ApoB Levels
- 01:47:55 Modifying Keto Diet for Better Health Outcomes
- 01:56:33 Plant-Based Diets and Fat Consumption
- 02:05:10 Understanding Lp(a) and Its Impact on Health
Related Resources
- Receive our free weekly email: the Sigma Synopsis
- Listen to the mentioned Sigma Nutrition podcast episode with Professor Chris Packard here
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Comments
Love this conversation! I think an effective format to engage with the likes of Saladino is with a written conversation. Then he can’t use his charismatic verbal and physical posturing to influence. Select an unbiased moderator. Establish a mutually agreed upon question to address. Invite replies and counter-arguments in a systematic way. What’s your best 2-3 studies to back up your position? Edit for brevity and clarity. Then publicize clips to draw people to read it.
I really appreciate all you do to counter the flood of misinformation online!