SNR #58: Ryan Lowery – HMB For Insane Mass and Strength Gains? Facts Behind The Study

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SNR #58
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SNR #58: Ryan Lowery – HMB For Insane Mass and Strength Gains? Facts Behind The Study

Episode 58: Ryan Lowery of the Human Performance Lab at the University of Tampa gives details of the study that showed insane increases in strength and muscle mass after a 12 week training program.


Guest Bio

Ryan Lowery



Ryan is a Senior Research Scientist under Dr. Jacob Wilson at the Human Performance Lab at the University of Tampa, FL.

His primary interests are sports nutrition, supplementation and training variables which optimize body composition (decrease bodyfat and increase muscle mass), strength, and power in various populations.

The state-of-the-art Human Performance lab has established itself as one of the most advanced in the world. In fact it was featured in the movie “Generation Iron”. Research has covered the cellular, molecular and whole body changes in muscle size, strength and power in response to resistance training and nutrition interventions.

HMB is an active metabolite of Leucine that reduces muscle protein breakdown.

In this episode we discuss:

  • The work currently carried out by the Human Performance Lab.
  • What is HMB and it’s proposed mechanism of action?
  • The difference between HMB-free acid and HMB-calcium
  • The methodology behind the group’s 2014 study
  • Results after the 12 week training protocol
  • Set-up and design of the study
  • Reaction to some criticisms of the study/results reported
  • What questions still need to be answered

Links & Resources:

Ryan Lowery on Twitter

The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study – Wilson et al.

The effects of ketogenic dieting on skeletal muscle and fat mass – Poster presentation,  Proceedings of the Eleventh International Society of Sports Nutrition (ISSN) Conference and Expo

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SNR #43: Dr. Mike Israetel – All You Need To Know About Nutrient Timing

SNR #28: Eric Helms ~ Dieting, Macros & Critical Thinking for Physique and Strength Athletes

SNR #24: Abbie Smith-Ryan ~ Performance supplementation, high intensity training & chronic low-calorie dieting