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Introduction
Discordance between low-density lipoprotein particle (LDL-p) and low-density lipoprotein cholesterol (LDL-C) occurs when the levels of these two biomarkers do not match up as expected. Discordance between Apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) is similar, except rather than counting just LDL particles, ApoB is a measure of the numbers of lipoproteins that have an ApoB attached.
Discordance between ApoB and LDL-C can lead to either an underestimate or overestimate of ASCVD risk. And therefore there may be important implications for someone who does have discordance. Additionally, it is such cases that suggest that a measurement of ApoB may provide additional information beyond traditional lipid measures in assessing a person’s cardiovascular risk.
Recent work from researchers at Liverpool John Moores University has investigated whether discordance is associated with certain dietary patterns.
In this episode, one of the researchers involved, Dr. Ian Davies, is on the podcast to discuss this work in addition to wider questions in the diet-lipids-CVD field that remain to be answered.
Related resources
- Join the Sigma newsletter for free
- Subscribe to Sigma Nutrition Premium
- Studies Mentioned:
- Mazidi et al., 2021 – Nutrient Patterns are Associated with Discordant Apolipoprotein B and Low-Density Lipoproteins
- Gjuladin-Hellon et al., 2018 – Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis
- Further Reading:
- Lipoproteins
- Atherogenic Potential of Lipoproteins
- LDL-C, LDL-P and ApoB
- Discordance
- Separation of Lipoproteins
- Diet Patterns & Discordance
- Saturated Fat & Blood Lipids
Guest Information
Click through to your app of choice to listen and subscribe:
He is currently a Reader in Nutritional Science at Liverpool John Moores University in the UK. His research interests have expanded over time, to cover a range of topics related to the effects of nutrition and lifestyle choices on cardio-metabolic (CM) markers relating to CVD risk.
His research has had international recognition and impacted upon nutrition policy with respect to dietary fat and cholesterol. Recent studies also include collaboration with epidemiologists to investigate low density lipoprotein discordant phenotypes and metabolic and clinical cardiovascular disease risk factors.
Danny Lennon has a master’s degree (MSc.) in Nutritional Sciences from University College Cork, and he is the founder of Sigma Nutrition.
Danny is currently a member of the Advisory Board of the Sports Nutrition Association, the global regulatory body responsible for the standardisation of best practice in the sports nutrition profession.
Introduction to this Episode
Discordance between low-density lipoprotein particle count (LDL-P) and low-density lipoprotein cholesterol (LDL-C) occurs when the levels of these two biomarkers do not match up as expected.
Discordance between Apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) is similar, except rather than counting just LDL particles, ApoB is a measure of the number of all lipoproteins that have an ApoB attached.
Discordance between ApoB and LDL-C can lead to either an underestimate or overestimate of ASCVD risk. And therefore there may be important implications for someone who does have discordance. Additionally, it is such cases that suggest that a measurement of ApoB may provide additional information beyond traditional lipid measures in assessing a personʼs cardiovascular risk.
Recent work from researchers at Liverpool John Moores University has investigated whether discordance is associated with certain dietary patterns.
In this episode, one of the researchers involved, Dr. Ian Davies, is on the podcast to discuss this work in addition to wider questions in the diet-lipids-CVD field that remain to be answered.
Connection to Previous Episodes
#381: Prof. Chris Packard – LDL Cholesterol, ApoB & Atherosclerosis
- Chris Packard holds an Honorary Professorship of Vascular Biochemistry at the University of Glasgow.
- Over his career, Professor Packard has focussed on two aspects of atherosclerosis research, lipoprotein metabolism and how it is affected by diets and drugs, and large-scale clinical trials of lipid lowering agents.
- He is acknowledged as one of the leading researchers in the world in this field.
- In this episode, we discuss, among many other things, atherosclerosis development and markers of risk (LDL-C, ApoB, non-HDL-C, etc.)
- You can find the episode page here.
