#239: Carl Juneau, PhD – Does Muscle Damage Actually Cause Hypertrophy?

Carl Juneau, PhD

Carl is an exercise scientist with a PhD in physical activity epidemiology. He is also the founder of the Dr. Muscle app.

• Influence of mechanical tension, muscle damage and metabolic stress on hypertrophy
• Does muscle damage really cause hypertrophy?
• Research for and against muscle damage being important.
• Practical implications
• Volume vs. mechanical tension

• Training for Hypertrophy: The Case Against Muscle Damage – Stronger By Science article
• Schoenfeld, 2010 – The mechanisms of muscle hypertrophy and their application to resistance training
• Damas et al., 2018 – The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis
• Schoenfeld Letter to the Editor IRT to Damas (2018): Exercise-Induced Muscle Damage and Hypertrophy: A Closer Look Reveals the Jury is Still Out
• Damas Reply to the letter to the Editor: “Exercise-Induced Muscle Damage and Hypertrophy: A Closer Look Reveals the Jury is Still Out”
• Damas et al., 2016 – Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage
• Brentano & Martens Kruel, 2011 – A review on strength exercise-induced muscle damage: applications, adaptation mechanisms and limitations
• Flann et al., 2011 – Muscle damage and muscle remodeling: no pain, no gain?
• Lixandrao et al., 2018 – Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis
• Loenneke et al., 2014 – Does blood flow restriction result in skeletal muscle damage? A critical review of available evidence
• NASA – Muscle Atrohpy
• Dr. Muscle App
• Carl Juneau on Facebook